Drutai has been published as a method review Sun et al. (2023) in European Journal of Medicinal Chemistry.
Beyond Drutai reported in this paper, many computational methods for drug discovery were also reviewed. Particularly, in the DeepsmirUD work Sun et al. (2023), connectivity scores were used to connect drugs and diseases through regulation of microRNA expression.
@article{SUN2023115500,
title = {Small molecule-mediated targeting of microRNAs for drug discovery: Experiments, computational techniques, and disease implications},
journal = {European Journal of Medicinal Chemistry},
volume = {257},
pages = {115500},
year = {2023},
issn = {0223-5234},
doi = {https://doi.org/10.1016/j.ejmech.2023.115500},
url = {https://www.sciencedirect.com/science/article/pii/S022352342300466X},
author = {Jianfeng Sun and Miaoer Xu and Jinlong Ru and Anna James-Bott and Dapeng Xiong and Xia Wang and Adam P. Cribbs},
keywords = {microRNA targets, Drug discovery, Molecular interactions, Disease implications, Deep learning},
}- Sun, J., Xu, M., Ru, J., James-Bott, A., Xiong, D., Wang, X., & Cribbs, A. P. (2023). Small molecule-mediated targeting of microRNAs for drug discovery: Experiments, computational techniques, and disease implications. European Journal of Medicinal Chemistry, 115500. https://doi.org/10.1016/j.ejmech.2023.115500
- Sun, J., Ru, J., Ramos-Mucci, L., Qi, F., Chen, Z., Chen, S., Cribbs, A. P., Deng, L., & Wang, X. (2023). DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning. International Journal of Molecular Sciences, 24(3). 10.3390/ijms24031878